HOME/東京都健康長寿医療センター研究所 老化制御研究チーム 分子老化制御

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2010 2009 2008年以前

研究実績 2012年

原著論文 総説および解説

原著論文

  1. Shimokawa, Y., Nakakoshi, M., Saito, S., Suzuki, H., Yokoyama, Y., Ishigami, A., Nishioka, H., Tsubuki, M. : Synthesis and Evaluation of 4-Aryl-2(1H)-quinolinones as Potent Amyloid β Fibrillogenesis Inhibitors. Heterocycles 85: 1933-1940 (2012)
  2. Suzuki, H., Ishigami, A., Orimoto, A., Matsuyama, A., Handa, S., Maruyama, N., Yokoyama, Y., Okuno, H., Nakakoshi, M.: Development of a new distyrylbenzene-derivative amyloid-β-aggregation and fibril formation inhibitor. Chem Pharm Bull 60: 1164-1170 (2012)
  3. Iwama, M., Kondo, Y., Shimokado, K., Maruyama, N., Ishigami, A. : Uric acid levels in tissues and plasma of mice during aging. Biol Pharm Bull 35: 1367-1370 (2012)
  4. Jang, B., Jeon, Y.C., Choi, J.K., Park, M., Kim, J.I., Ishigami, A., Maruyama, N., Carp, R.I., Kim, Y.S., Choi, E.K. : Peptidylarginine deiminase modulates the physiological roles of enolase via citrullination: links between altered multifunction of enolase and neurodegenerative diseases. Biochem J 445: 183-192 (2012)
  5. Mori, S., Kishi, M., Kubo, S., Akiyoshi, T., Yamada, S., Miyazaki, T., Konishi, T., Maruyama, N., Shigemoto, K. : 3,4-diaminopyridine improves neuromuscular transmission in a MuSK antibodies-induced mouse model of myasthenia gravis. J Neuroimmunol 245: 75-78 (2012)
  6. Sato, Y., Arai, K.Y., Nishiyama, T., Nomura, Y., Kishimoto, Y., Aizawa, S., Maruyama, N., Ishigami, A. : Ascorbic acid deficiency leads to epidermal atrophy and UVB-induced skin pigmentation in SMP30/GNL knockout hairless mice. J Invest Dermatol 132: 2112-2115 (2012)
  7. Iwama, M., Amano, A., Shimokado, K., Maruyama, N., Ishigami, A. : Ascorbic acid levels in various tissues, plasma and urine of mice during aging. J Nutr Sci Vitaminol 58: 169-174 (2012)
  8. Senmaru, T., Yamasaki, M., Okada, H., Asano, M., Fukui, M., Nakamura, N., Obayashi, H., Kondo, Y., Maruyama, N., Ishigami, A., Hasegawa, G. : Pancreatic insulin release in vitamin C deficient senescence marker protein 30/gluconolactonase knockout mice. J Clin Biochem Nutr 50: 114-118 (2012)
  9. Mori, S., Kubo, S., Akiyoshi, T., Yamada, S., Miyazaki, T., Hotta, H., Desaki, J., Kishi, M., Konishi, T., Nishino, Y., Miyazawa, A., Maruyama, N., Shigemoto, K.: Antibodies against Muscle-Specific Kinase Impair Both Presynaptic and Postsynaptic Functions in a Murine Model of Myasthenia Gravis. Amr J Pathol 180: 798-810 (2012)
  10. Ishikawa, Y., Hashizume, K., Kishimoto, S., Tezuka, Y., Nishigori, H., Yamamoto, N., Kondo, Y., Maruyama, N., Ishigami, A., Kurosaka, D.: Effect of vitamin C depletion on UVR-B induced cataract in SMP30/GNL knockout mice. Exp Eye Res 94: 85-89 (2012)
  11. Saito, K., Yokoyama, T., Yoshida, H., Kim, H., Shimada, H., Yoshida, Y., Iwasa, H., Shimizu, Y., Yoshitaka, K., Handa, S., Maruyama, N., Ishigami, A., Suzuki, T.: A Significant Relationship between Plasma Vitamin C Concentration and Physical Performance among Japanese Elderly Women. J Gerontol A Biol Sci Med Sci 67: 295-301 (2012)
  12. Kondo, Y., Higashi, C., Iwama, M., Ishihara, K., Handa, S., Mugita, H., Maruyama, N., Koga, H., Ishigami, A.: Bioavailability of vitamin C from mashed potatoes and potato chips after oral administration in healthy Japanese men. Br J Nutr 107: 885-892 (2012)

総説および解説

  1. 石神昭人: カロリー制限しても寿命は延びない. ビタミン 86: 690-692 (2012)
  2. 石神昭人: ビタミンの老化制御.HORMONE FRONTIER IN GYNECOLOGY 19: 231-236 (2012)
  3. 石神昭人、小池建吾、佐藤匡、丸山直記、瀬山邦明: ビタミンCと老化、呼吸器疾患.THE LUNG perspectives 20: 182-185 (2012)

 

 

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