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研究実績 2008年以前

2001 2002 2003 2004 2005 2006 2007 2008

2008

原著論文

  1. Furusawa, H., Sato, Y., Tanaka, Y., Inai, Y., Amano, A., Iwama, M., Kondo, Y., Handa, S., Murata, A., Nishikimi, M., Goto, S., Maruyama, N., Takahashi, R., Ishigami, A.: Vitamin C is not essential for carnitine biosynthesis in vivo: verification in vitamin C-depleted senescence marker protein-30/gluconolactonase knockout mice. Biol Pharm Bull 31: 1673-1679 (2008)
  2. Jang, B., Kim, E., Choi, J.K., Jin, J.K., Kim, J.I., Ishigami, A., Maruyama, N., Carp, R.I., Kim, Y.S., Choi, E.K.: Accumulation of citrullinated proteins by up-regulated peptidylarginine deiminase 2 in brains of scrapie-infected mice: a possible role in pathogenesis. Am J Pathol 173: 1129-1142 (2008)
  3. Kondo, Y., Sasaki, T., Sato, Y., Amano, A., Aizawa, S., Iwama, M., Handa, S., Shimada, N., Fukuda, M., Akita, M., Lee, J., Jeong, K.S., Maruyama, N., Ishigami, A.: Vitamin C depletion increases superoxide generation in brains of SMP30/GNL knockout mice. Biochem Biophys Res Commun 377: 291-296 (2008)
  4. Park, J.K., Jeong, D.H., Park, H.Y., Son, K.H., Shin, D.H., Do, S.H., Yang, H.J., Yuan, D.W., Hong, I.H., Goo, M.J., Lee, H.R., Ki, M.R., Ishigami, A., Jeong, K.S.: Hepatoprotective effect of Arazyme on CCl4-induced acute hepatic injury in SMP30 knock-out mice. Toxicology 246: 132-142 (2008)
  5. Rath, B., Pandey, R.S., Debata, P.R., Maruyama, N., Supakar, P.C.: Molecular characterization of senescence marker protein-30 gene promoter: identification of repressor elements and functional nuclear factor binding sites. BMC Mol Biol 9: 43 (2008)
  6. Sato, Y., Kajiyama, S., Amano, A., Kondo, Y., Sasaki, T., Handa, S., Takahashi, R., Fukui, M., Hasegawa, G., Nakamura, N., Fujinawa, H., Mori, T., Ohta, M., Obayashi, H., Maruyama, N., Ishigami, A.: Hydrogen-rich pure water prevents superoxide formation in brain slices of vitamin C-depleted SMP30/GNL knockout mice. Biochem Biophys Res Commun 375: 346-350 (2008)
  7. Shigemoto, K., Kubo, S., Jie, C., Hato, N., Abe, Y., Ueda, N., Kobayashi, N., Kameda, K., Mominoki, K., Miyazawa, A., Ishigami, A., Matsuda, S., Maruyama, N.: Myasthenia gravis experimentally induced with muscle-specific kinase. Ann N Y Acad Sci 1132: 93-98 (2008)

総説および解説

  1. 近藤嘉高: 老化と活性酸素. 栄養科学トピックス: (2008)
  2. 近藤嘉高, 石神昭人: ヒト赤血球ではstomatin がGlut1と結合することによりデヒドロアスコルビン酸を取り込む. ビタミン 82: 516-518 (2008)
  3. 近藤嘉高, 石神昭人, 丸山直記: 老化とバイオマーカー. 医学のあゆみ 227: 563-566 (2008)
  4. 石神昭人: ビタミンC不足は慢性閉塞性肺疾患の発症リスクを高める. ビタミン 82: 39-42 (2008)
  5. 浅賀宏昭, 石神昭人: ヒト表皮におけるシトルリン化タンパク質の動態. 医学と生物学 152: 26-33 (2008)

著書

  1. 石神昭人: SMP30/GNLノックアウトマウス. 老化・老年病研究のための動物実験ガイドブック: 108-114 (2008)

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2007

原著論文

  1. Asaga, H., Ishigami, A.: Microglial expression of peptidylarginine deiminase 2 in the prenatal rat brain. Cell Mol Biol Lett 12: 536-544 (2007)
  2. Ishigami, A., Maruyama, N.: Significance of SMP30 in Gerontology. Geriatrics & Gerontology International 7: 316-325 (2007)
  3. Kimura, Y., Kubo, S., Koda, H., Noguchi, Y., Sawabe, M., Maruyama, N., Kitamura, K.: Quantitative analysis of mRNA in human temporal bones. Acta Otolaryngol 127: 1024-1030 (2007)
  4. Ohta, K., Shigemoto, K., Fujinami, A., Maruyama, N., Konishi, T., Ohta, M.: Clinical and experimental features of MuSK antibody positive MG in Japan. Eur J Neurol 14: 1029-1034 (2007)

総説および解説

  1. 丸山直記, 重本和宏: 神経筋接合部疾患における抗MuSK抗体と病態機序. CLINICAL NEUROLOGY 47: 842-844 (2007)
  2. 佐藤匡, 瀬山邦明, 石神昭人, 丸山直記: 肺の老化メカニズム. THE LUNG perspectives 15: 155-160 (2007)
  3. 石神昭人: ビタミンCの不足が老化に及ぼす影響. ビタミン 81: 303-308 (2007)

このページの先頭へ

2006

原著論文

  1. Chiba, T., Kondo, Y., Shinozaki, S., Kaneko, E., Ishigami, A., Maruyama, N., Umezawa, K., Shimokado, K.: A selective NFkappaB inhibitor, DHMEQ, reduced atherosclerosis in ApoE-deficient mice. J Atheroscler Thromb 13: 308-313 (2006)
  2. Jung, K.J., Maruyama, N., Ishigami, A., Yu, B.P., Chung, H.Y.: The redox-sensitive DNA binding sites responsible for age-related downregulation of SMP30 by ERK pathway and reversal by calorie restriction. Antioxid Redox Signal 8: 671-680 (2006)
  3. Kondo, Y., Inai, Y., Sato, Y., Handa, S., Kubo, S., Shimokado, K., Goto, S., Nishikimi, M., Maruyama, N., Ishigami, A.: Senescence marker protein 30 functions as gluconolactonase in L-ascorbic acid biosynthesis, and its knockout mice are prone to scurvy. Proc Natl Acad Sci U S A 103: 5723-5728 (2006)
  4. Sato, T., Seyama, K., Sato, Y., Mori, H., Souma, S., Akiyoshi, T., Kodama, Y., Mori, T., Goto, S., Takahashi, K., Fukuchi, Y., Maruyama, N., Ishigami, A.: Senescence marker protein-30 protects mice lungs from oxidative stress, aging, and smoking. Am J Respir Crit Care Med 174: 530-537 (2006)
  5. Shigemoto, K., Kubo, S., Maruyama, N., Hato, N., Yamada, H., Jie, C., Kobayashi, N., Mominoki, K., Abe, Y., Ueda, N., Matsuda, S.: Induction of myasthenia by immunization against muscle-specific kinase. J Clin Invest 116: 1016-1024 (2006)
  6. Son, T.G., Zou, Y., Jung, K.J., Yu, B.P., Ishigami, A., Maruyama, N., Lee, J.: SMP30 deficiency causes increased oxidative stress in brain. Mech Ageing Dev 127: 451-457 (2006)
  7. Yumura, W., Imasawa, T., Suganuma, S., Ishigami, A., Handa, S., Kubo, S., Joh, K., Maruyama, N.: Accelerated tubular cell senescence in SMP30 knockout mice. Histol Histopathol 21: 1151-1156 (2006)

総説および解説

  1. 重本和宏, 丸山直記: 重症筋無力症の新たな病因・病態. BIO Clinica 21: 886-890 (2006)
  2. 重本和宏, 久保幸穂, 丸山直記: 抗MuSK抗体陽性重症筋無力症の病因と病態. 基礎老化研究 30: 25-30 (2006)
  3. 石神昭人: ビタミンCが不足すると老化が加速する機能性食品・サプリメント評価系への応用. Food style 21 10: 30-33 (2006)
  4. 石神昭人, 佐藤安訓, 丸山直記: 機能解明! SMP30はビタミンC合成に重要な酵素. 基礎老化研究 30: 11-14 (2006)
  5. 湯村和子, 板橋美津世, 今澤俊之, 丸山直記, 鈴木和男: 老化と腎臓  老化と腎—免疫機能— 腎と透析 60: 987-991 (2006)

このページの先頭へ

2005

原著論文

  1. Feng, D., Imasawa, T., Nagano, T., Kikkawa, M., Takayanagi, K., Ohsawa, T., Akiyama, K., Ishigami, A., Toda, T., Mitarai, T., Machida, T., Maruyama, N.: Citrullination preferentially proceeds in glomerular Bowman's capsule and increases in obstructive nephropathy. Kidney Int 68: 84-95 (2005)
  2. Ishigami, A., Fujita, T., Inoue, H., Handa, S., Kubo, S., Kondo, Y., Maruyama, N.: Senescence marker protein-30 (SMP30) induces formation of microvilli and bile canaliculi in Hep G2 cells. Cell Tissue Res 320: 243-249 (2005)
  3. Ishigami, A., Ohsawa, T., Hiratsuka, M., Taguchi, H., Kobayashi, S., Saito, Y., Murayama, S., Asaga, H., Toda, T., Kimura, N., Maruyama, N.: Abnormal accumulation of citrullinated proteins catalyzed by peptidylarginine deiminase in hippocampal extracts from patients with Alzheimer's disease. J Neurosci Res 80: 120-128 (2005)
  4. Ishii, K., Tsubaki, T., Fujita, K., Ishigami, A., Maruyama, N., Akita, M.: Immunohistochemical localization of senescence marker protein-30 (SMP30) in the submandibular gland and ultrastructural changes of the granular duct cells in SMP30 knockout mice. Histol Histopathol 20: 761-768 (2005)

総説および解説

  1. 丸山直記, 石神昭人: 老年病におけるシトルリン化蛋白質の病態生理学的意義. 日本老年医学会雑誌 42: 519-522 (2005)
  2. 丸山直記, 石神昭人: 蛋白質のシトルリン化と病態. 最新医学 60: 2498-2501 (2005)
  3. 丸山直記, 石神昭人, 近藤嘉高: 老化の分子異常〜臨床検査医学への貢献. 臨床病理 53: 728-734 (2005)
  4. 森貴紀, 瀬山邦明, 石神昭人, 丸山直記, 福地義之助: Senescence marker protein-30ノックアウトマウス. 分子呼吸器病 9: 55-60 (2005)
  5. 石神昭人, 山本尚吾, 田口ひろみ, 丸山直記: アルツハイマー病でのシトルリン化蛋白質の異常な蓄積. 日本未病システム学会雑誌 11: 84-85 (2005)

このページの先頭へ

2004

原著論文

  1. Feng, D., Kondo, Y., Ishigami, A., Kuramoto, M., Machida, T., Maruyama, N.: Senescence marker protein-30 as a novel antiaging molecule. Ann N Y Acad Sci 1019: 360-364 (2004)
  2. Ishigami, A., Kondo, Y., Nanba, R., Ohsawa, T., Handa, S., Kubo, S., Akita, M., Maruyama, N.: SMP30 deficiency in mice causes an accumulation of neutral lipids and phospholipids in the liver and shortens the life span. Biochem Biophys Res Commun 315: 575-580 (2004)
  3. Jung, K.J., Ishigami, A., Maruyama, N., Takahashi, R., Goto, S., Yu, B.P., Chung, H.Y.: Modulation of gene expression of SMP-30 by LPS and calorie restriction during aging process. Exp Gerontol 39: 1169-1177 (2004)
  4. Kondo, Y., Ishigami, A., Kubo, S., Handa, S., Gomi, K., Hirokawa, K., Kajiyama, N., Chiba, T., Shimokado, K., Maruyama, N.: Senescence marker protein-30 is a unique enzyme that hydrolyzes diisopropyl phosphorofluoridate in the liver. FEBS Lett 570: 57-62 (2004)
  5. Maruyama, N., Ishigami, A., Kuramoto, M., Handa, S., Kubo, S., Imasawa, T., Seyama, K., Shimosawa, T., Kasahara, Y.: Senescence marker protein-30 knockout mouse as an aging model. Ann N Y Acad Sci 1019: 383-387 (2004)
  6. Matsuyama, S., Kitamura, T., Enomoto, N., Fujita, T., Ishigami, A., Handa, S., Maruyama, N., Zheng, D., Ikejima, K., Takei, Y., Sato, N.: Senescence marker protein-30 regulates Akt activity and contributes to cell survival in Hep G2 cells. Biochem Biophys Res Commun 321: 386-390 (2004)
  7. Mori, T., Ishigami, A., Seyama, K., Onai, R., Kubo, S., Shimizu, K., Maruyama, N., Fukuchi, Y.: Senescence marker protein-30 knockout mouse as a novel murine model of senile lung. Pathol Int 54: 167-173 (2004)

総説および解説

  1. 丸山直記, 石神昭人, 瀬山邦明: 老化とCOPD 遺伝子から見た老化と臓器変化. COPD FRONTIER 3: 315-318 (2004)
  2. 近藤嘉高, 石神昭人, 下門顕太郎, 丸山直記: SMP30の抗老化作用と分子機能の検討. 基礎老化研究 28: 29-32 (2004)
  3. 石神昭人, 丸山直記: シトルリン化蛋白質と関節リウマチ. 医学のあゆみ 211: 253-254 (2004)

このページの先頭へ

2003

原著論文

  1. Guerrin, M., Ishigami, A., Mechin, M.C., Nachat, R., Valmary, S., Sebbag, M., Simon, M., Senshu, T., Serre, G.: cDNA cloning, gene organization and expression analysis of human peptidylarginine deiminase type I. Biochem J 370: 167-174 (2003)
  2. Ishigami, A., Handa, S., Maruyama, N., Supakar, P.C.: Nuclear localization of senescence marker protein-30, SMP30, in cultured mouse hepatocytes and its similarity to RNA polymerase. Biosci Biotechnol Biochem 67: 158-160 (2003)

総説および解説

  1. 石神昭人, 丸山直記: SMP30ノックアウトマウス - 新しい老化モデルマウスとしての可能性 -. 基礎老化研究 27: 35-40 (2003)

このページの先頭へ

2002

原著論文

  1. Asaga, H., Akiyama, K., Ohsawa, T., Ishigami, A.: Increased and type II-specific expression of peptidylarginine deiminase in activated microglia but not hyperplastic astrocytes following kainic acid-evoked neurodegeneration in the rat brain. Neurosci Lett 326: 129-132 (2002)
  2. Ishigami, A., Asaga, H., Ohsawa, T., Akiyama, K., Maruyama, N.: Protein deimination and peptidylarginine deiminase expression during cornification of rat epidermal keratinocytes. Biomed. Res. 23: 145-151 (2002)
  3. Ishigami, A., Fujita, T., Handa, S., Shirasawa, T., Koseki, H., Kitamura, T., Enomoto, N., Sato, N., Shimosawa, T., Maruyama, N.: Senescence marker protein-30 knockout mouse liver is highly susceptible to tumor necrosis factor-α- and Fas-mediated apoptosis. Am J Pathol 161: 1273-1281 (2002)
  4. Ishigami, A., Ohsawa, T., Asaga, H., Akiyama, K., Kuramoto, M., Maruyama, N.: Human peptidylarginine deiminase type II: molecular cloning, gene organization, and expression in human skin. Arch Biochem Biophys 407: 25-31 (2002)
  5. Ishii, K., Abe, K., Tsubaki, K., Yamamoto, M., Akita, M., Ishigami, A., Maruyama, N.: [Localization of senescence marker protein-30 (SMP30) in the mouse submandibular gland and histological findings in the SMP30 knock-out mouse]. Nippon Jibiinkoka Gakkai Kaiho 105: 915-919 (2002)

総説および解説

  1. 丸山直記, 石神昭人, 倉元雅史: 加齢臓器障害の分子機序とその克服. 生体の科学 53: 425-431 (2002)

このページの先頭へ

2001

原著論文

  1. Asaga, H., Ishigami, A.: Protein deimination in the rat brain after kainate administration: citrulline-containing proteins as a novel marker of neurodegeneration. Neurosci Lett 299: 5-8 (2001)
  2. Asaga, H., Nakashima, K., Senshu, T., Ishigami, A., Yamada, M.: Immunocytochemical localization of peptidylarginine deiminase in human eosinophils and neutrophils. J Leukoc Biol 70: 46-51 (2001)
  3. Ishigami, A., Asaga, H., Ohsawa, T., Akiyama, K., Maruyama, N.: Peptidylarginine deiminase type I, type II, type III and type IV are expressed in rat epidermis. Biomedical Research 22: 63-65 (2001)
  4. Ishigami, T., Fujita, T., Simbula, G., Columbano, A., Kikuchi, K., Ishigami, A., Shimosawa, T., Arakawa, Y., Maruyama, N.: Regulatory effects of senescence marker protein 30 on the proliferation of hepatocytes. Pathol Int 51: 491-497 (2001)
  5. Ohsawa, T., Ishigami, A., Akiyama, K., H., A.: Immunocytochemical localization of peptidylarginine deiminase type III, trichohyalin and deiminated trichohyalin in infant rat dorsal skin hair follicle. Biomedical Research 22: 91-97 (2001)
  6. Ohsawa, T., Ishigami, A., Akiyama, K., H., A.: Morphogenesis- and hair cycle-dependent expression of trichohyalin, peptidylarginine deiminase type III and deiminated trichohyalin in rat dorsal skin hair folicles. Biomedical research 22: 265-271 (2001)

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